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Researcher Loren Pickart, PhD, who first isolated GHK from human plasma, described it as having a "profound effect on the reset of human genes toward a more youthful state." More recent genomic analyses confirm that GHK-Cu shifts gene expression patterns in aging tissue toward patterns characteristic of much younger tissue effectively acting as a biological reset at the cellular level

It had limited food-supplement GRAS history in some jurisdictions but Australia's TGA placed it on Schedule 4 (prescription) in 2020

Hypertension 41 , 625633 (2003)

Acetyl Tetrapeptide-3 Laboratory Studies Stimulation of Extracellular Matrix Proteins Maat et al